David S. Haymer, Ph.D.

University of Hawaii at Manoa

Biomedical Sciences Bldg. Rm T510

Honolulu HI 96813

Tel:     808-956-5517
Fax:    808-956-xxxx

Email :  dhaymer@hawaii.edu

Pubmed Link 


Molecular population genetics. 

We are investigating the use of genetic markers to study the population dynamics of insect pest species.  Most recently, we have used a PCR-RFLP approach based on variation in intron sequences of the glucose-6-phosphate dehydrogenase (Zw) gene to assess genetic variability in 26 populations and infestations of the Mediterranean fruit fly, Ceratitis capitata. From this, surveys were conducted to document genotypes and allele frequencies in these samples and to document the relationships of existing populations and the invasion process represented by new infestations of this insect pest.  In addition, for at least some of the infestations, populations that are most likely to be acting as sources of origin have been identified. We are also using a similar approach to document evolutionary relationships of species forming a complex.

Cloning and characterization of genes involved in sex determination.

We are using a differential hybridization approach to identify genes involved in the sex determination process in several insect pest species. We have identified a number of candidate genes that appear to be expressed in only one sex. These are being analyzed to determine the extent to which they may be involved in the sex determination process.


Hsu JC, Chien TY, Hu CC, Chen MJ, Wu WJ, Feng HT, Haymer DS, Chen CY.  2012. Discovery of genes related to insecticide resistance in Bactroera dorsalis by functional genomic analysis of a de novo assembled transcriptrome. PLos One. 2012;7(8):e40950.

Hsu JC, Haymer DS, Chou MY, Feng HT, Chen HH, Huang YB, Mau RF. 2012. Monitoring resistance to spinosad in the melon fly (Bactrocera cucurbitae) in Hawaii and Taiwan. ScientificWorldJournal. 2012;2012:750576.

Elfekih S, Haymer DS. 2010. Molecular taxonomic identification of Dacus and Ceratitis species from Sub-Saharan Africa using mitochondrial haplotypes. J Econ Entomol. Oct;103(5): 1842-7

Huang GC, Hsu JC, Haymer D, Lin GC, Wu WJ. 2009. Rapid identification of the Mediterranean fruit fly(Diptera: Tephritidae) by loop-mediated isothermal amplification. J Econ Entomol. Jun;102(3):1239-46

Hsu JC, Wu WJ, Haymer DS, Liao HY, Feng HT. 2008. Alterations of the acetylcholinesterase enzyme in the oriental fruit fly Bactrocera dorsalis are correlated with resistance to the organophosphate insecticide fenitrothion. Insect Biochem Mol Biol. Frb;38(2):146-54. Epub 2007 Oct 11


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