Mariana Gerschenson, Ph.D.

Professor and Chair

Cell and Molecular Biology Graduate Program

John A. Burns School of Medicine

University of Hawaii at Manoa

651 Ilalo St, Room 222B

Honolulu HI 96813

Email: gerschen@hawaii.edu




Website:

http://www.hawaii.edu/hacrp/gerschen.htm and http://www.cellmolecularbiology.org/faculty/gerschensonm.html


PubMedID: http://www.ncbi.nlm.nih.gov/pubmed?term=%22Gerschenson%20M%22%5BAuthor%5D


Education


Ph.D., 1993, University of Colorado, Health Sciences Center, Denver, CO

B.A.,   1986, University of Colorado, Boulder, CO


RESEARCH INTERESTS


Research in Dr. Gerschenson’s lab studies mitochondria in human cells and tissues.  We are interested in adult and pediatric metabolic diseases (HIV and non-HIV insulin resistance, diabetes, obesity, fat, muscle, and liver tissue), neurological diseases (HIV peripheral neuropathy and HIV associated dementia), immunological diseases, and cancer.  We conduct local, national, international clinical studies to obtain blood, cheek cells, fat tissue, urine, and cerebrospinal fluid, etc. to study mitochondrial genetics, energy metabolism, oxidative stress, cell death.  We are also interested in how cytokines regulate mitochondrial genes via transcription and cell signaling. 


TECHNIQUES


Protein Chemistry, e.g. Immunoassays, Multiplexing, Western Blot analysis, ELISAs

Molecular Biology, e.g. Real time PCR, Reverse Transcriptase PCR, Southern Blot analysis

Histology and Immunohistochemistry

Clinical translational research 



SELECTED RECENT PUBLICATIONS:


Phanuphak N, Ananworanich J, Teeratakulpisarn N, Jadwattanakul T, Kerr SJ, Chomchey N, Hongchookiat P, Mathajittiphun P, Pinyakorn S, Rungrojrat P, Praihirunyakit P, Gerschenson M, Phanuphak P, Valcour V, Kim JH, Shikuma C; SEARCH 003 Study Group.  Antivir Ther. 2012;17(8):1521-31.


McComsey GA, Daar ES, O’Riordan M, Collier AC, Kosmiski L, Santana JL, Fichtenbaum CJ, Fink H, Sax PE, Libutti DE, Gerschenson,M. Changes in Fat Mitochondrial DNA and Function in Subjects Randomized to Abacavir-Lamivudine or Tenofovir DF-Emtricitabine With Atazanavir-Ritonavir or Efavirez: AIDS Clinical Trials Group Study A5224s, Substudy of A5202. J Infect Dis. 2013 Feb;207(4):604-11.


Armah KA, McGinnis K, Baker J, Gibert C, Butt AA, Bryant KJ, Goetz M, Tracy R, Oursler KK, Rimland D, Crothers K, Rodriguez-Barradas M, Crystal S, Gordon A, Kraemer K, Brown S, Gerschenson M, Leaf DA, Deeks SG, Rinaldo C, Kuller LH, Justice A, Freiberg M. HIV Status, Burden of Comorbid Disease, and Biomarkers of Inflammation, Altered Coagulation, and Monocyte Activation. Clin Infect Dis. 2012 Jul;55(1):126-36.


Hulgan T, Gerschenson, M. HIV and Mitrochondria: More Than Just Drug Toxicity. J Infect Dis. 2012 Jun 15;205(12):1769-71.


McComsey GA, O’Riordan M, Choi J, Libutti D, Rowe D, Storer N, Harrill D, Gerschenson M. Mitochondrial Function, Inflammation, Fat and Bone in HIV Lioatrophy: Randomized Study of Uridine Supplementation or Switch to Tenofovir. Antivir Ther. 2012; 17(2) : 347-53.


Shikuma CM, Seto T , Liang CY, Bennett K, DeGruttola V, Gerschenson M, Stein JH, Budoff M, Hodis HN, Delaney JA, Ogata-Arakiki D, Pramyothin P, Chow D. Vitamin D levels and Markers of Arterial Dysfunction in HIV.  AIDS Resv HumnRetroviruses. 2012Aug:28(8):793-7.


Chow DC, Wood R, Choi J, Grandinetti A, Gerschneson M, Sriratanaviriyakul N, Nakamoto B, Shikuma C, Low P. Cardiovagal Autonomic Function in HIV-Infected Patients With unsuppressed HIV Viremia. HIV Clin Trials. 2011 May-Jun;12(3);141-50.


Gerschenson M, Courtney K, Berzins B, Taiwo B, Libutti DE, Choi J, Chen D, Weinstein J, Shore J, DaSilva B, Belsey E, McComsey GA, and Murphy RL. Mitochondrial Function, Morphology, and Metabolic Parameters Improve After Switching From Stavudine to a Tenofovir-Containing Regimen. Journal of Antimicrobial Chemotherapy, 63(6); 1244-50, 2009.


McComsey, G.A., Libutti, D.E., O’Riordan, M., Shelton, J.M., Storer, N., Ganz, J., Jasper, J., Harrill, D., and Gerschenson, M.  Mitochondrial RNA and DNA alterations in HIV lipoatrophy are linked to antiretroviral therapy and not to HIV infection. Antiviral Therapy, 13(5): 715-22, 2008.


Shikuma, C.M., Gerschenson, M., Chow D., LiButti, D.E., Willis J.H., Murray, J., Capaldi, R.A., and Marusich, M. Mitochondrial Oxidative Phosphorylation Protein Levels in Peripheral Blood Mononuclear Cells Correlate with Levels in Subcutaneous Adipose Tissue Within Samples Differing by HIV and Lipoatrophy AIDS Research and Human Retrovirus, 24(10): 1255-62, 2008.



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