Andrea Fleig, Ph.D.

Adjunct Professor of Cell and Molecular Biology

John A. Burns School of Medicine

Director, Clinical Research

The Queen’s Medical Center

1356 Lusitana St, UHT 619

Honolulu HI 96813

Email: afleig@hawaii.edu

Website: http://qcbr.jabsom.hawaii.edu/

PubMedID:


Education

Ph.D., 1993, University of Hawaii, Honolulu, HI

MS, 1989, University of Konstanz, Konstanz, Germany


RESEARCH INTERESTS

The focus of Dr. Fleig’s research interest revolves around cellular signaling events as they relate to health and disease. Over the past 20 years, Dr. Fleig has been using biophysical and pharmacological approaches elucidating ion channel function and its relationship to cell signaling. Mediated by very rewarding collaborations she was able to incorporate molecular aspects to this work leading to the original identification and biophysical as well as functional characterization of several novel ion channels. One of these, TRPM7, has been implicated in anoxia-mediated cell death following ischemia and emerges as a key regulator of cell proliferation with therapeutic implications for cancer treatment. The results of Dr. Fleig’s work identified TRPM7 to be at the nexus of mechanisms that regulate both cellular and whole body magnesium homeostasis in mammals.


Research rotations in the Fleig laboratory will provide the opportunity to gain expertise in the following methodologies:


TECHNIQUES:

Electrophysiology and Fluorescence Imaging

Molecular and Cell Biological Techniques.


RECENT PUBLICATIONS:

Kivi B., Poerzgen P., Penner R., Horgen F.D., Fleig A. (2010) Development and Optimization of a high-throughput bioassay for TRPM7 ion channel inhibitors. J. Biomol. Screen 15:498-507.


Ryazanova L.V., Rondon L.J., Zierler S., Hu Z., Galli J., Yamaguchi T.P., Mazur A., Fleig A., Ryazanov A. (2010) TRPM7 controls magnesium homeostasis in mammals. Nature Communications 1: 109.

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