Frederick P. Bellinger, Ph.D.

Assistant Researcher

Department of Cell and Molecular Biology

John A. Burns School of Medicine

University of Hawaii at Manoa

651 Ilalo St, Room 222-19

Honolulu HI 96813

Email: fb@hawaii.edu

Website: http://www2.hawaii.edu/~fb


Education


Ph.D., University of Queensland, Brisbane, QLD, Australia

M.S. San Diego State University, CA, USA

B.A. California State University, Northridge, CA, USA


RESEARCH INTERESTS


Our current research focuses on the different roles of members of the selenoprotein family in brain function and neurological disorders. Selenoproteins are proteins that contain the strong antioxidant element selenium in the form of selenocysteine, 21st amino acid. We’ve recently found that one family member, Selenoprotein P (Sepp1), is associated with neuropathology of Alzheimer’s disease. We have also recently found that another member, Selenoprotein M (SelM), has roles in neuroprotection from oxidative stress and regulation of external calcium. We are currently examining the roles of these and other selenoproteins neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases, as well as their roles in neuron physiology. 


TECHNIQUES


Electrophysiology (hippocampus slice and LTP), Calcium Imaging, Immunohistochemistry and immunofluorescence, Confocal Microscopy, RNA Expression Analysis with qPCR, Protein Expression Analysis, Control of Protein Expression with RNAi and microRNAs.


RECENT PUBLICATIONS


Bellinger, F.P., He, Q.P., Bellinger, M.T., Lin, Y., Raman, A.V., White, L.R., Berry, M.J. (2008). Association of Selenoprotein P with Alzheimer’s Pathology in Human Cortex. Journal of Alzheimer’s Disease 15:465-472.

Bellinger, F.P., Reeves, Raman, A.V., M.A., Berry, M.J. (2009). Regulation and Function of Selenoproteins in Human Diseases. Biochemical Journal 422:11-22.

Reeves, M.A., Bellinger, F.P., Berry, M.J. (2010). The Neuroprotective Capacity of Selenoprotein M. Antioxidant Redox Signaling. 12:809-818.

Takemoto, A.S., Berry, M.J., Bellinger, F.P. (2010). Role of Selenoprotein P in Alzheimer’s Disease. Ethnicity and Disease 20:S1 92-95

Bellinger, F.P.,  Bellinger, M.T., Seale, L.A., Takemoto, A.S.,Raman, A.V., Miki, T., Manning-Bog, A.B., Berry, M.J., White, L.R., Ross, G.W. (2011) Glutathione Peroxidase 4 is Associated with Neuromelanin in Substantia Nigra and Dystropic Axons in Putamen of Parkinson’s Brain. Molecular Neurodegeneration, 6:8. 

Raman, A,V., Pitts, M. W., Seyedali, A., Hashimoto, A.C., Seale, L.A., Bellinger, F.P., Berry, M.J.(2012) Absence of Selenopeotein P but not selenocysteine lyase results in severe neurological dysfunction. Genes, Brain and Behavior 11:601-613.

Seale, L.A., Hashimoto, A.C., Kurokawa, S., Gilman, C.L., Seyedali, A., Bellinger, F.P., Raman, A.V., Berry, M.J.(2012) Disruption of the Selenocysteine Lyase-Mediated Selenium Recycling Pathway Leads to Metabolic Syndrome in Mice. Molecular Cell Biology 2012 Aug 13.

Bellinger, F.P., Raman, A.V., Rueli, R.H., Bellinger, M.T., Dewing, A.S., Seale, L. A., Andres, M.A., Uyehara-Lock, J. H., White, L.R., Ross, G.H., Berry, M.J., (2012). Changes in Selenoprotein P in Substantia Nigra and Putamen in Parkinson’s Disease. 2: 115-126.

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